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Journal: Journal of proteomics & bioinformatics
Article Title: Misclassification Errors in Unsupervised Classification Methods. Comparison Based on the Simulation of Targeted Proteomics Data
doi: 10.4172/jpb.S14-005
Figure Lengend Snippet: On the determination of the right number of clusters. Figures 11A, 11C and 11E misclassification error versus effect size when the correct number of clusters (five) is known and provided to the k-means algorithm (R=0.0001, 0.45 and 0.9). Number of patients P=100, 500. Number of proteins in the assay N=1129. Completely overlapping signatures, ‘among neighbors’ correlation of proteins R ij =R ∣i-j∣ . Figures 11B, 11D and 11F illustrate the situation where the correct number of clusters is not provided to the k-means algorithm but is evaluated by the evalclusters.m function based on the values of 4 criteria: Calinski-Harabasz, Davies-Bouldin, Gap and Silhoutte. Note that as everywhere in this paper, each point is an average of 12 simulations; therefore the optimal number of clusters is not necessary integer number. Note that Gap criterion performs much better than the rest of criteria, but even for Gap the required effect size for correct prediction of the number of clusters is substantially higher than the one required for correct classification when the number of clusters is known.
Article Snippet: Instead, the
Techniques: